Don Love CURRICULUM VITAE

Tertiary Education:

1. 1982 PhD, Biochemistry, The University of Adelaide.
2. 1977 BSc, (II-1 class Honours) Biochemistry, The University of Adelaide.
3. 1976 BSc, The University of Adelaide.

Distinctions/Honours:

1. 2007 Member of the Institute of Food Science and Technology (U.K.), Chartered Scientist
2. 2006 Fellow of the Royal Society of Medicine (U.K.)
3. 2005 Fellow of the Royal College of Pathologists (U.K)
4. 2005 Fellow of the Institute of Biology (UK), Chartered Biologist
5. 2005 Fellow of the Linnean Society
6. 2005 Member of the Institute of Biomedical Science (UK)
7. 1987-1991 Visiting Member of Common Room, Wolfson College, Oxford. 1987-1991.
8. 1976  Commonwealth Postgraduate Research Scholarship (Australia)
9. 1972 Commonwealth University Scholarship (Australia)

Employment Record:

1. 2007-present Director of Diagnostic Genetics, LabPLUS, Auckland City Hospital (0.8 FTE)
2. 1999-present Associate Professor (Molecular Genetics), School of Biological Sciences, University of Auckland,
3. 1999-April 2007 (full-time), May 2007-present (0.25 FTE).
4. 1993-1999 Senior Lecturer (Molecular Genetics), School of Biological Sciences, University of Auckland
5. 1991-1993 Senior Research Associate, Department of Pathology, University of Cambridge
6. 1987-1991 Research Associate, Nuffield Department of Clinical Medicine, John Radcliffe Hospital, University of Oxford
7. 1982-1987 Research Fellow, Department of Cell Biology, University of Auckland

Other information

Present research/professional speciality:
My present research concerns the molecular-based diagnosis of human disorders, and the modelling of human disorders in zebrafish (Danio rerio).  Much of the latter has involved a significant investment in quantitating the levels of endogenous transcripts.  The former has involved the development of high throughput approaches to genome analysis, and the recent development of high resolution genome analysis using Affymetrix and Agilent arrays, with a parallel investment in using the Sequenom MassARRAY platform for SNP and RNA quantitation studies.

PUBLICATIONS 2003 - present

1. Stapleton PM, Lai D, Wu E, Millar CD, Love DR (2008). Discovery of three related females who type XY at the amelogenin locus. Forensic Science International: Genetics supplement series, accepted.
2. Eddy C-A, MacCormick J, Crawford JR, Chung S-K, Love DR, Rees MI, Skinner JR and Shelling AN (2008). Identification of large gene rearrangements in KCNQ1 and KCNH2 in patients with long QT syndrome. Heart Rhythm, accepted.
3. Grainger PA, Love DR, Walker MF, Dommels Y, Butts C, Rowan D, Roy NC, Helsby N, Browning BL, Zhu S, Copp BR and Ferguson LR (2008). Allantoin as a biomarker of inflammation in an inflammatory bowel disease mouse model: NMR analysis of urine. The Open Biomarkers Journal, accepted.
4. Lan C-C, Copp BR, Cattin PM and Love DR (2007). Whole organism approaches to drug discovery: the promising role of zebrafish (Danio rerio). Expert Opinion in Drug Discovery, 2(10): 1-13.
5. Tang R, Dodd A, Lai D, McNabb WC and Love DR (2007). Validation of zebrafish (Danio rerio) reference genes for quantitative real time RT-PCR normalization. Acta Biochimica et Biophysica Sinica, 39(5):384-390.
6. Love DR, Lan C-C, Dodd A, Shelling AN, McNabb WC and Ferguson LR (2007). Modelling Inflammatory Bowel Disease: the zebrafish as a way forward. Expert Review in Molecular Diagnostics, 7(2): 177-193.
7. Dodd A, Greenwood DR, Miller AL, Webb SE, Chambers SP, Copp BR and Love DR (2006) Zebrafish: at the nexus of functional and chemical genomics. Biotech Gen Eng Rev, 22:77-99.
8. Love DR, Dodd A, Tsai A, Copp BR and Greenwood DR (2005). Zebrafish: a high biological value screening platform. Screening: Trends in Drug Discovery, 2:2-4.
9. Love DR, Pichler FB, Dodd A, Copp BR and Greenwood D (2004). Technology for high throughput screens: the present and the future using zebrafish. Current Opinion in Biotechnology, 15:1-8.
10. Pichler FB, Dodd A and Love DR (2004). Global gene expression analysis in the zebrafish: the challenge and the promise. Drug Discovery Today: Technologies, 1(2):79-84.
11. Love DR, Chambers SP, Cox S, Curtis P, Dodd A, Laurenson S, Maguire GM, Pichler FP, Williams LC and Copp BR. Disease modelling: the zebrafish as a manipulable gene expression programme. NZ Bioscience, August 2004.
12. Dodd A, Chambers SP and Love DR (2004). Short interfering RNA-mediated gene targeting in the zebrafish. FEBS Letters, 561(1-3):89-93
13. Hegde MR, Wu F, Chong B, Chin ELH, Hutchinson DO, Richards CS, Khadilkar S and Love DR (2004). Limb-girdle muscular dystrophy: use of dHPLC and direct sequencing to detect sarcoglycan gene mutations in a New Zealand cohort. Clinical Genetics, 65: 55-60.
14. Chong B, Hegde M, Fawkner M, Simonet S, Cassinelli H, Coker M, Kanis J, Seidel J, Tau C, Tüysüz B, Yüksel B, Love D and Cundy T (2003). Idiopathic hyperphosphatasia and TNFRSF11B mutations: relationships between phenotype and genotype. J Bone and Mineral Research, 18(12): 2095-2104.
15. Pichler FB, Laurenson S, Williams LC, Dodd A, Copp BR and Love DR (2003). Chemical discovery and global gene expression analysis in zebrafish. Nature Biotechnology, 21(8): 879-883.
16. Chambers SP, Anderson LVB, Maguire GM, Dodd A and Love DR (2003). Sarcoglycans of the zebrafish: orthology and localization to the sarcolemma and myosepta of muscle. Biochem Biophys Res Comm, 303(2):488-495.
17. West PMH, Love DR, Stapleton PM, and Winship IM (2003). Paternal uniparental disomy in monozygotic twins discordant for hemihypertrophy. J Med Genet, 40(3):223-226.

Book chapters

1. Ramachandran A, Black MA, Shelling AN and Love DR (2008). Microarrays: analysis of signalling pathways. Methods in Molecular Medicine, Vol 141: Clinical Bioinformatics, pp115-130 (Trent R, Ed.) Human Press Inc., USA.
2. Dodd A, Chambers SP, Nielsen PE and Love DR (2004). Modeling human disease by gene targeting. The Zebrafish: Cellular and Developmental Biology (Second Edition). Methods in Cell Biology, Chapter 27, Volume 76. Eds: Detrich HW, Westerfield M and Zon LI. Elsevier Inc.
   Pichler F, Black M, Williams LC and Love DR (2004).
3. Design, normalization, and analysis of spotted microarray data. The Zebrafish: Genetics, Genomics and Informatics (Second Edition). Methods in Cell Biology, Chapter 28, Volume 77. Eds: Detrich HW, Westerfield M and Zon LI. Elsevier Inc.

Other

1. Love DR, Chambers SP, Cox S, Curtis P, Dodd A, Laurenson S, Maguire GM, Pichler FP, Williams LC and Copp BR. Disease modelling: the zebrafish as a manipulable gene expression programme. NZ Bioscience, August 2004.
2. Love DR. Animal-based research: a need for informed dialogue. Bioscience News & Advocate, Guest Editorial- Social and Ethical Issues, 12th February, 2004
    http://www.bioscinews.com/files/news-detail.asp?NewsID=6188
    (also disseminated by AnimalNet Feb. 12/04)
3. Love DR. The use of animals in research: the road we've come down, and the road ahead. New Zealand Science Teachers 2003, Volume 104.